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BR 100u/mg
Synonym Pancreatic Ribonuclease
Ribonuclease I
Ribonucleate 3′-pyrimidinooligonucleotidohydrolase
RNase A
MDL number MFCD00132181
EG/EC Number 232-646-6
Application
• RNase protection assays
• Remove unspecifically bound RNA
• Analysis of RNA sequences
• Hydrolyze RNA contained in protein samples
• Purification of DNA
Pancreatic RNase A specifically cleaves at the 3′-side of pyrimidine (uracil
or cytosine) phosphate bonds. Ribonucleases do not hydrolyze DNA, because the
DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase
can also hydrolyze RNA from protein samples.